![]() ![]() ![]() Group IV received a combination of 6.25 mg/kg BW DLBS1Y62 and 20 mg/kg BW attapulgite. Groups I, II, and III received 6.25, 12.5, and 25 mg/kg BW DLBS1Y62, respectively. Positive controls were treated with 2 mg/kg BW loperamide orally as a suspension. Negative controls received 0.05 mL purified water. 18 Animals were divided into six groups, each consisting of five rats, and were fasted for 4 hours before treatment, with free access to water. The experiment was carried out according to the methods of Girard et al (2005) 17 and Sharma et al (2012). gambir Roxb., named DLBS1Y62, on castor oil-induced diarrhea and castor oil-induced enteropooling in Wistar rats. 16 In this study, we evaluate the antidiarrheal effect of the dried sap extract of U. 15 Uncaria gambir extract has been used for the treatment of diarrhea and dysentery, and as an astringent medicine, in Asian countries. ( Gambier) is a member of the Rubiaceae family which contains diverse and complex secondary metabolites, and particularly alkaloids and tannins. Some studies have researched the traditional use of antidiarrheal medicinal plants by investigating the biological activity of extracts of such plants, which contain phytochemicals (such as alkaloids, tannins, flavonoids, and terpenes) that are thought to be responsible for the antidiarrheal activity. 12 A study showed that inappropriate practices in the management of childhood diarrhea were prevalent these included the curtailment of fluids and breastfeeding, food restriction, and the use of inappropriate medication, which can result in a higher risk of mortality or prolongation of the diarrhea condition. For bloody diarrhea or severe dehydration in cases of suspected cholera, the guideline suggests antimicrobials. In addition, the WHO guideline recommends that children experiencing non-severe dehydration should receive oral rehydration therapy with oral rehydration solution in a health facility. 11įirst line management of diarrhea for children under 5 years old comprises continued feeding, increased fluids, and supplemental zinc for 10–14 days to prevent dehydration. 10 Castor oil is a stimulant laxative agent that could be used for inducing a diarrhea model. 9 More than 700 drugs, including laxatives, have been implicated in causing diarrhea. 7 Besides bacterial infection, diarrhea can be caused by drugs, psychological factors, allergies, 8 and food poisoning. 6 This imbalance is possibly caused by an overstimulation of bacterial enterotoxins and inflammation, leading to the releases of prostaglandins in the intestinal mucosa. 5 Excessive loss of fluid in diarrhea is associated with an imbalance between the absorptive and secretory mechanisms of water and electrolytes in the intestinal tract, accompanied by hypermotility. 4ĭiarrhea is the frequent passage of liquid feces (three times in a 24-hour period) and it is characterized by increased gastrointestinal motility and secretion. 3 Excessive loss of fluid in diarrhea causes dehydration, which leads to death in a short time, especially in children. 2 In Indonesia, diarrhea is the third leading cause of child death. 1 WHO and Unicef have stated that there are about two billion cases of diarrheal disease worldwide every year and 1.9 million children die from diarrhea each year, mostly in developing countries. ![]() Diarrhea is a common illness worldwide and it is the second leading cause of mortality among children under 5 years old. ![]()
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